Mannose-binding lectin의 선천성 면역과 질병에 대한 역할
기관명 | NDSL |
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저널명 | 생명과학회지 |
ISSN | , |
ISBN |
저자(한글) | 장호정,박정혜,정경태,동의대학교,동의대학교,동의대학교 |
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저자(영문) | |
소속기관 | |
소속기관(영문) | |
출판인 | |
간행물 번호 | |
발행연도 | 2010-01-01 |
초록 | Innate immunity is the first line of host defense consisting of various molecules against infectious challenges. Mannose-binding lectin (MBL) belongs to the collectin protein family which takes part of innate immunity and is able to recognize specific carbohydrates on the surface of a variety of infectious agents acting as a pattern recognition molecule. In this way, MBL differentiates self from non-self and interacts with other molecules of the immune system. MBL genotype shows various MBL2 polymorphisms which are responsible for MBL deficiency in a substantial portion of the entire human population and for susceptibility to infectious disease. Therefore, it has been highlighted in the relationship between genetic variants and clinical significance. Here we focus on presenting anoverview of our understanding of MBL structure and functions. |
원문URL | http://click.ndsl.kr/servlet/OpenAPIDetailView?keyValue=03553784&target=NART&cn=ATN0026988678 |
첨부파일 |
과학기술표준분류 | |
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ICT 기술분류 | |
DDC 분류 | |
주제어 (키워드) | Mannose-binding lectin,innate immunity,C-type lectin,infectious disease,Mannose-binding lectin,innate immunity,C-type lectin,infectious disease |